Qualitative Simulation of Genetic Regulatory Networks: Method and Application


Hidde de Jong 1 , Michel Page 1; 3 ,Céline Hernandez 1 , and Johannes Geiselmann 2

1 INRIA Rhône-Alpes, 655 avenue de l’Europe, Montbonnot, 38334 Saint Ismier CEDEX, France

2 PEGM, Université Joseph Fourier, 460 rue de la Piscine, BP 53, 38041 Grenoble CEDEX 9

3 ESA, Université Pierre Mendès France, {Hidde.de-Jong, Celine.Hernandez, Michel.Page}@inrialpes.fr, Hans.Geiselmann@ujf-grenoble.fr


Abstract: Computer modeling and simulation are indispensable for understanding the functioning of an or-ganism on a molecular level. We present an implemented method for the qualitative simulation of large and complex genetic regulatory networks. The method allows a broad range of regulatory interactions between genes to be represented and has been applied to the analysis of a real network of biological interest, the network controlling the inititation of sporulation in the bacterium B. subtilis.


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